Казаков Александр Сергеевич

 


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 Hypolipidemic / antihyperlipidemic / lipid-lowering drugs are a diverse group of pharmaceuticals that are used in the treatment of hyperlipidemias.

There are several classes of hypolipidemic drugs. They may differ in both their impact on the cholesterol profile and adverse effects. For example, some may lower the  low density lipoprotein (LDL) ("bad cholesterol") more so than others, while others may preferentially increase high density lipoprotein (HDL), "the good cholesterol".

Classes of hypolipidemic drugs :

Ø  Statins (or HMG-CoA reductase inhibitors) are a class of drugs that reduce cholesterol by inhibiting the enzyme HMG-CoA which has a central role in producing cholesterol in the liver. 

 

  

These drugs share a commonality of the end of their name.  This makes recognition of drugs from other drugs easy.  Atorvastatin, Fluvastatin, Lovastatin, Pitavastatin, Pravastatin, Rosuvastatin and Simvastatin are particularly well-suited for lowering LDL, the cholesterol with the strongest links to vascular diseases.

In studies using standard doses, statins have been found to lower LDL-C by 18% to 55%, depending on the specific statin being used. There is a risk of severe muscle damage - myopathy (muscular weakness, muscle cramps, stiffness, spasm) & rhabdomyolysis (destruction of muscle cells; damaged skeletal striated muscle breaks down rapidly). Hypercholesterolemia is not a risk factor for mortality in persons older than 70 years and risks from statin drugs are more increased after age 85.

 

Ø  Fibrates (Bezafibrate, Ciprofibrate, Clofibrate, Gemfibrozil, Fenofibrate, Clinofibrate) are indicated for hypertriglyceridemia. Fibrates typically lower triglycerides by 20% to 50%. Level of the good cholesterol HDL is also increased. Fibrates may decrease LDL, though generally to a lesser degree than statins. Similar to statins, there is a risk of severe muscle damage (myopathy & rhabdomyolysis)

Ø  Niacin ( nicotinic acid = vitaminPP= vitamin B3) is also well-suited for lowering triglycerides by 20–50%. It may also lower LDL by 5–25% and increase HDL by 15–35%. Niacin may cause hyperglycemia, and may also cause liver damage. The niacin derivative acipimox is also associated with a modest decrease in LDL.

Ø  Bile acid sequestrants (Cholestyramine, Colestipol, Colesevelam) are particularly effective for lowering LDL by sequestering the cholesterol-containing bile acids released into the intestine and preventing their reabsorption from the intestine. Bile acid sequestrants may cause gastrointestinal problems, and may also reduce the absorption of other drugs and vitamins from the gut.

Ø  Phytosterols may be found naturally in plants. Phytosterols reduce the absorption of cholesterol in the gut. Hence, they are most effective when consumed with meals.

Orlistat (Xenical): Its primary function is to prevent the absorption of about 30% of fats from the human diet; thereby reducing caloric intake (a drug designed to treat obesity) is by inhibiting Pancreatic lipase- an enzyme that breaks down triglycerides in the intestine.

 

Микроблог:

2018-04-20 13:10:58
Вниманию студентов групп МЛ-306,
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2018-04-19 11:50:23
Вниманию студентов групп МС305 и
МС306!
С 23 апреля по техническим причинам
занятия переносятся со вторника на
субботу!
МС-305- суббота 9-45- 12-10
МС-306- суббота 15-35- 18-00


2017-06-05 10:22:58
Прием отработок и коллоквиумов на
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состоится: вторник (06/06/2017)
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